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1

Multiple C-terminal tail Ca2+/CaMs regulate CaV1.2 function but do not mediate channel dimerization

Kim, Eun Young, Rumpf, Christine H, Van Petegem, Filip, Arant, Ryan J, Findeisen, Felix, Cooley, Elizabeth S, Isacoff, Ehud Y, Minor, Daniel L

Journal:

The EMBO Journal

Year:

2010

Language:

english

File:

PDF, 2.21 MB

english, 2010

2

Ryanodine Receptors: Allosteric Ion Channel Giants

Van Petegem, Filip

Journal:

Journal of Molecular Biology

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

3

Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation–Contraction Complex

Pancaroglu, Raika, Van Petegem, Filip

Journal:

Annual Review of Genetics

Year:

2018

Language:

english

File:

PDF, 4.13 MB

english, 2018

4

A multi-dimensional analysis of genotypeâphenotype discordance in malignant hyperthermia susceptibility

Ibarra Moreno, Carlos A., Kraeva, Natalia, Zvaritch, Elena, Figueroa, Lourdes, Rios, Eduardo, Biesecker, Leslie, Van Petegem, Filip, Hopkins, Philip M., Riazi, Sheila

Journal:

British Journal of Anaesthesia

Year:

2020

File:

PDF, 768 KB

2020

5

Crystal structures of a psychrophilic metalloprotease reveal new insights into catalysis by cold-adapted proteases

Nushin Aghajari, Filip Van Petegem, Vincent Villeret, Jean-Pierre Chessa, Charles Gerday, Richard Haser, Jozef Van Beeumen

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2003

Language:

english

File:

PDF, 765 KB

english, 2003

6

Folding properties of the hepatitis B core as a carrier protein for vaccination research

Michiel Etienne Janssens, Dirk Geysen, Katleen Broos, Ine De Goeyse, Johan Robbens, Filip Van Petegem, Jean-Pierre Timmermans, Yves Guisez

Journal:

Year:

2010

Language:

english

File:

PDF, 475 KB

english, 2010

7

The structural biology of ryanodine receptors

Lynn Kimlicka, Filip Van Petegem

Journal:

SCIENCE CHINA Life Sciences

Year:

2011

Language:

english

File:

PDF, 1.46 MB

english, 2011

8

Multiple C-terminal tail Ca2+/CaMs regulate CaV1.2 function but do not mediate channel dimerization

Kim, Eun Young, Rumpf, Christine H, Van Petegem, Filip, Arant, Ryan J, Findeisen, Felix, Cooley, Elizabeth S, Isacoff, Ehud Y, Minor, Daniel L

Journal:

The EMBO Journal

Year:

2010

Language:

english

File:

PDF, 47 KB

english, 2010

9

Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain

Van Petegem, Filip, Clark, Kimberly A., Chatelain, Franck C., Minor, Daniel L.

Journal:

Year:

2004

Language:

english

File:

PDF, 394 KB

english, 2004

10

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

Tung, Ching-Chieh, Lobo, Paolo A., Kimlicka, Lynn, Van Petegem, Filip

Journal:

Year:

2010

Language:

english

File:

PDF, 1.10 MB

english, 2010

11

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain–Ca2+/calmodulin complex

Petegem, Filip Van, Chatelain, Franck C, Minor,, Daniel L

Journal:

Nature Structural and Molecular Biology

Year:

2005

Language:

english

File:

PDF, 545 KB

english, 2005

12

Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL+ chronic myeloid leukemia cells to tyrosine kinase inhibitors

Xiaohu Liu, Min Chen, Paolo Lobo, Jianghong An, S.W. Grace Cheng, Annie Moradian, Gregg B. Morin, Filip Van Petegem, Xiaoyan Jiang

Journal:

Year:

2012

Language:

english

File:

PDF, 1.27 MB

english, 2012

13

Alanine-Scanning Mutagenesis Defines a Conserved Energetic Hotspot in the CaVα1 AID-CaVβ Interaction Site that Is Critical for Channel Modulation

Filip Van Petegem, Karl E. Duderstadt, Kimberly A. Clark, Michelle Wang, Daniel L. Minor Jr.

Journal:

Year:

2008

Language:

english

File:

PDF, 1.70 MB

english, 2008

14

Structures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation

Eun Young Kim, Christine H. Rumpf, Yuichiro Fujiwara, Elizabeth S. Cooley, Filip Van Petegem, Daniel L. Minor Jr.

Journal:

Year:

2008

Language:

english

File:

PDF, 1.90 MB

english, 2008

15

Crystal Structures of the N-Terminal Domains of Cardiac and Skeletal Muscle Ryanodine Receptors: Insights into Disease Mutations

Paolo Antonio Lobo, Filip Van Petegem

Journal:

Year:

2009

Language:

english

File:

PDF, 3.69 MB

english, 2009

16

The Deletion of Exon 3 in the Cardiac Ryanodine Receptor Is Rescued by β Strand Switching

Paolo A. Lobo, Lynn Kimlicka, Ching-Chieh Tung, Filip Van Petegem

Journal:

Year:

2011

Language:

english

File:

PDF, 1.09 MB

english, 2011

17

Disease Mutations in the Ryanodine Receptor Central Region: Crystal Structures of a Phosphorylation Hot Spot Domain

Zhiguang Yuchi, Kelvin Lau, Filip Van Petegem

Journal:

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

18

Crystal structure of Sulfolobus acidocaldarius aspartate carbamoyltransferase in complex with its allosteric activator CTP

Dirk De Vos, Ying Xu, Tony Aerts, Filip Van Petegem, Jozef J. Van Beeumen

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 852 KB

english, 2008

19

Crystal Structure of T State Aspartate Carbamoyltransferase of the Hyperthermophilic Archaeon Sulfolobus acidocaldarius

Dirk De Vos, Filip Van Petegem, Han Remaut, Christianne Legrain, Nicolas Glansdorff, Jozef J. Van Beeumen

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 2.00 MB

english, 2004

20

Understanding Nicotinamide Dinucleotide Cofactor and Substrate Specificity in Class I Flavoprotein Disulfide Oxidoreductases: Crystallographic Analysis of a Glutathione Amide Reductase

Filip Van Petegem, Dirk De Vos, Savvas Savvides, Bjorn Vergauwen, Jozef Van Beeumen

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 1.06 MB

english, 2007

21

Crystal Structure of the Talin Integrin Binding Domain 2

Tsz Ying Sylvia Cheung, Michael J. Fairchild, Raz Zarivach, Guy Tanentzapf, Filip Van Petegem

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.66 MB

english, 2009

22

Seeing the Forest through the Trees: towards a Unified View on Physiological Calcium Regulation of Voltage-Gated Sodium Channels

Van Petegem, Filip, Lobo, Paolo A., Ahern, Christopher A.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 830 KB

english, 2012

23

Biochemical and Functional Characterization of Crystallographic Ca2+/CaM-Cav1.2 A-C-IQ Complex Dimer

Kim, Eun Young, Rumpf, Christine, Van Petegem, Filip, Arant, Ryan, Cooley, Elizabeth S., Isacoff, Ehud Y., Minor, Daniel L.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 37 KB

english, 2010

24

Structural Basis for Calcium Modulation of the Cardiac Sodium Channel

Sarhan, Maen, Van Petegem, Filip, Ahern, Christopher

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

25

Structural Insights into the Assembly and Function of the IP3 Receptor Ligand-Binding Module

Yuchi, Zhiguang, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 43 KB

english, 2012

26

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

Kimlicka, Lynn, Lau, Kelvin, Tung, Ching-Chieh, Van Petegem, Filip

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 2.91 MB

english, 2013

27

The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations

Kimlicka, Lynn, Tung, Ching-Chieh, Carlsson, Anna-Carin Cecilia, Lobo, Paolo Antonio, Yuchi, Zhiguang, Van Petegem, Filip

Journal:

Year:

2013

Language:

english

File:

PDF, 2.83 MB

english, 2013

28

Talin Autoinhibition Is Required for Morphogenesis

Ellis, Stephanie J., Goult, Benjamin T., Fairchild, Michael J., Harris, Nathan J., Long, Jenny, Lobo, Paolo, Czerniecki, Stefan, Van Petegem, Filip, Schöck, Frieder, Peifer, Mark, Tanentzapf, Guy

Journal:

Current Biology

Year:

2013

Language:

english

File:

PDF, 2.37 MB

english, 2013

29

Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms

Lau, Kelvin, Chan, Mandy M. Y., Van Petegem, Filip

Journal:

Year:

2014

Language:

english

File:

PDF, 2.43 MB

english, 2014

30

Crystal Structure of the Navβ4 Extracellular Domain

Das, Samir, Gilchrist, John, Bosmans, Frank, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 46 KB

english, 2014

31

Evolution, Structure and Function of Ryanodine Receptor Domains

Yuchi, Zhiguang, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 44 KB

english, 2014

32

The Ryanodine Receptor N-Terminal Disease Hot Spot Intersubunit Interface is Disrupted by Channel Opening and Affected by Disease Mutations Acting via Long-Range Structural Changes

Kimlicka, Lynn, Lau, Kelvin, Tung, Ching-Chieh, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 36 KB

english, 2012

33

Crystallographic Investigation of Several Malignant Hyperthermia and CPVT Mutations in Ryanodine Receptors

Kimlicka, Lynn, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 38 KB

english, 2011

34

Crystallographic Basis for Calcium Regulation of Sodium Channels

Sarhan, Maen, Van Petegem, Filip, Ahern, Christopher A.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 39 KB

english, 2012

35

Studies in the Binding of Calmodulin to Skeletal and Cardiac Ryanodine Receptors

Lau, Kelvin, Chan, Mandy M.Y., Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

36

Structural Insight into the Phosphorylation Domain in Ryanodine Receptors

Yuchi, Zhiguang, Lau, Kelvin, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 38 KB

english, 2013

37

A Conserved Double-Tyrosine Motif in the Cardiac Sodium Channel Domain III-IV Linker Underlies Calcium Dependent Ca2+/Calmodulin Binding and Regulation of Inactivation Gating

Sarhan, Maen, Van Petegem, Filip, Ahern, Christopher

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 35 KB

english, 2010

38

The N-Terminal Disease Hot Spot of Ryanodine Receptors Forms a Cytoplasmic Vestibule

Van Petegem, Filip, Tung, Ching-Chieh, Lobo, Paolo A., Kimlicka, Lynn

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

39

The General Anaesthetic Binding Site of Calmodulin Disrupts Ryanodine Peptide Binding

Brath, Ulrika, Lau, Kelvin, Van Petegem, Filip, Erdélyi, Máté

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 41 KB

english, 2013

40

Calcium Dysregulation of Voltage-Gated Sodium Channels Harboring LQT3 Mutations

Sarhan, Maen, Van Petegem, Filip, Ahern, Christopher A.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 80 KB

english, 2012

41

Crystallographic Insights into the Cardiac Ryanodine Receptor N-terminal Domain and its Disease Mutants

Lobo, Paolo A., Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 41 KB

english, 2010

42

Conformational Dynamics inside Amino-Terminal Disease Hotspot of Ryanodine Receptor

Zhong, Xiaowei, Liu, Ying, Zhu, Li, Meng, Xing, Wang, Ruiwu, Van Petegem, Filip, Wagenknecht, Terence, Chen, S.R. Wayne, Liu, Zheng

Journal:

Year:

2013

Language:

english

File:

PDF, 2.47 MB

english, 2013

43

Conformational Dynamics Inside Amino-Terminal Disease Hotspot of Ryanodine Receptor

Zhong, Xiaowei, Liu, Ying, Meng, Xing, Wang, Ruiwu, Van Petegem, Filip, Wagenknecht, Terence, Wayne Chen, S.R., Liu, Zheng

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 36 KB

english, 2012

44

β Strand Switching: A Novel Structural Rescue Mechanism in a Δexon3 Cardiac Ryanodine Receptor Mutant

Lobo, Paolo A., Kimlicka, Lynn, Tung, Ching-Chieh, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 38 KB

english, 2011

45

Crystal Structure of Cardiac Ryanodine Receptor N-Terminal Region Contains Unique Anion Binding Site Targeted by Disease-Associated Mutations

Kimlicka, Lynn, Tung, Ching-Chieh, Carlsson, Anna-Carin C., Lobo, Paolo A., Yuchi, Zhiguang, Van Petegem, Filip

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 51 KB

english, 2014

46

Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic α-Helix That Transitions to a β-Strand in a Mutant Linked with a Heritable Cardiomyopathy

Amador, Fernando J., Kimlicka, Lynn, Stathopulos, Peter B., Gasmi-Seabrook, Geneviève M.C., MacLennan, David H., Van Petegem, Filip, Ikura, Mitsuhiko

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.76 MB

english, 2013

47

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain

Lau, Kelvin, Van Petegem, Filip

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 2.82 MB

english, 2014

48

Mapping the sevoflurane-binding sites of calmodulin

Brath, Ulrika, Lau, Kelvin, Van Petegem, Filip, Erdélyi, Máté

Journal:

Pharmacology Research & Perspectives

Year:

2014

Language:

english

File:

PDF, 1.61 MB

english, 2014

49

The CPVT-associated RyR2 mutation G230C enhances store overloadinduced Ca 2+ release and destabilizes the N-terminal domains

Liu, Yingjie, Kimlicka, Lynn, Hiess, Florian, Tian, Xixi, Wang, Ruiwu, Zhang, Lin, Jones, Peter P., Van Petegem, Filip, Chen, S. R. Wayne

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 740 KB

english, 2013

50

Roles of the NH 2 -terminal Domains of Cardiac Ryanodine Receptor in Ca 2+ Release Activation and Termination

Liu, Yingjie, Sun, Bo, Xiao, Zhichao, Wang, Ruiwu, Guo, Wenting, Zhang, Joe Z., Mi, Tao, Wang, Yundi, Jones, Peter P., Van Petegem, Filip, Chen, S. R. Wayne

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 4.63 MB

english, 2015